Version 5.4
Homo sapiens Protein: BAALC
Summary
InnateDB Protein IDBP-374700.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAALC
Protein Name brain and acute leukemia, cytoplasmic
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000395024
InnateDB Gene IDBG-31581 (BAALC)
Protein Structure
UniProt Annotation
Function May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11707601}. Membrane {ECO:0000269PubMed:11707601}. Note=Postsynaptic lipid rafts. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm- derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin. {ECO:0000269PubMed:11707601}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR009728 BAALC
PFAM PF06989
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXS3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 79870
UniGene Hs.700538
RefSeq NP_001019543
HUGO HGNC:14333
OMIM 606602
CCDS CCDS47906
HPRD 09422
IMGT
EMBL AF363578 AF371319 AF371323 AK022077 BC011517 BC035038
GenPept AAH11517 AAH35038 AAL50377 AAL50378 AAL50379 AAL50380 AAL50381 AAL50382 AAL50515 AAL50519 BAB13960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca