Version 5.4
Homo sapiens Protein: BLCAP
Summary
InnateDB Protein IDBP-374701.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLCAP
Protein Name bladder cancer associated protein
Synonyms BC10;
Species Homo sapiens
Ensembl Protein ENSP00000397172
InnateDB Gene IDBG-74305 (BLCAP)
Protein Structure
UniProt Annotation
Function May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. {ECO:0000269PubMed:17031575}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma. {ECO:0000269PubMed:10197429, ECO:0000269PubMed:16675915, ECO:0000269PubMed:19908260}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0030262 apoptotic nuclear changes
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018015 Bladder cancer-related BC10-like
PFAM PF06726
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62952
PhosphoSite PhosphoSite-
TrEMBL A2A2K9
UniProt Splice Variant
Entrez Gene 10904
UniGene Hs.743223
RefSeq NP_001161292
HUGO HGNC:1055
OMIM 613110
CCDS CCDS13295
HPRD 16552
IMGT
EMBL AF053470 AL109614 BC047692 BC071704
GenPept AAC06370 AAH47692 AAH71704 CAC00475 CAM19261

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca