Version 5.4
Homo sapiens Protein: ALS2CL
Summary
InnateDB Protein IDBP-374719.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALS2CL
Protein Name ALS2 C-terminal like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000413223
InnateDB Gene IDBG-30633 (ALS2CL)
Protein Structure
UniProt Annotation
Function Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. {ECO:0000269PubMed:15388334, ECO:0000269PubMed:16473597, ECO:0000269PubMed:17239822}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15388334, ECO:0000269PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
Disease Associations
Tissue Specificity Expressed in heart and kidney. {ECO:0000269PubMed:15388334}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR003123 Vacuolar sorting protein 9
IPR003409 MORN motif
PFAM PF00621
PF02204
PF02493
PRINTS
PIRSF
SMART SM00325
SM00698
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60I27
PhosphoSite PhosphoSite-Q60I27
TrEMBL G3V0I7
UniProt Splice Variant
Entrez Gene 259173
UniGene Hs.517937
RefSeq NP_001177636
HUGO HGNC:20605
OMIM 612402
CCDS CCDS2743
HPRD 10643
IMGT
EMBL AB107015 AC104304 AC134504 AK092455 AK093844 AK126505 AK131270 AK131273 BC042906 BC061883 BC075825 BC109233 CH471055 CR627258
GenPept AAH42906 AAH61883 AAH75825 AAI09234 BAC03895 BAC04237 BAC86572 BAD18448 BAD18450 BAD51817 CAH10367 EAW64776 EAW64777 EAW64778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca