Version 5.4
| Homo sapiens Protein: TNS3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-374807.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TNS3 | ||||||||||||||||||
| Protein Name | tensin 3 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000388318 | ||||||||||||||||||
| InnateDB Gene | IDBG-15881 (TNS3) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity). {ECO:0000250}. | ||||||||||||||||||
| Subcellular Localization | Cell junction, focal adhesion {ECO:0000269PubMed:15140944, ECO:0000269PubMed:17643115}. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. {ECO:0000269PubMed:11559528, ECO:0000269PubMed:15140944, ECO:0000269PubMed:16461921}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000008
C2 domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR014020 Tensin phosphatase, C2 domain IPR029021 Protein-tyrosine phosphatase-like IPR029023 Tensin phosphatase, lipid phosphatase domain |
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| PFAM |
PF00168
PF10409 |
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| PRINTS |
PR00360
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| PIRSF | |||||||||||||||||||
| SMART |
SM00239
SM00404 |
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q68CZ2 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q68CZ2 | ||||||||||||||||||
| TrEMBL | C9JWN9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 64759 | ||||||||||||||||||
| UniGene | Hs.520814 | ||||||||||||||||||
| RefSeq | |||||||||||||||||||
| HUGO | HGNC:21616 | ||||||||||||||||||
| OMIM | 606825 | ||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB062750 AC073341 AC092000 AF378756 AF417489 AK092864 BC071791 BC137133 BC137134 CH471128 CR749644 | ||||||||||||||||||
| GenPept | AAH71791 AAI37134 AAI37135 AAL11993 AAN32667 AAQ96841 BAB60681 BAC03993 CAH18438 EAW61011 | ||||||||||||||||||