InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGGT1B

Summary

InnateDB Protein

IDBP-374854.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGGT1B

Protein Name

protein geranylgeranyltransferase type I, beta subunit

Synonyms

BGGI; GGTI;

Species

Homo sapiens

Ensembl Protein

ENSP00000404676

InnateDB Gene

IDBG-37705 (PGGT1B)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269PubMed:8106351}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004661	protein geranylgeranyltransferase activity
GO:0004662	CAAX-protein geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0019840	isoprenoid binding
GO:0042277	peptide binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0018344	protein geranylgeranylation
GO:0034097	response to cytokine
GO:0045787	positive regulation of cell cycle
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process