InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDC4

Summary

InnateDB Protein

IDBP-37487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDC4

Protein Name

enhancer of mRNA decapping 4

Synonyms

Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8;

Species

Homo sapiens

Ensembl Protein

ENSP00000351811

InnateDB Gene

IDBG-37485 (EDC4)

Protein Structure

UniProt Annotation

Function

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269PubMed:16364915}.

Subcellular Localization

Cytoplasm, P-body. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0008150	biological_process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle