Version 5.4
Homo sapiens Protein: DNAJB14
Summary
InnateDB Protein IDBP-374947.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJB14
Protein Name DnaJ (Hsp40) homolog, subfamily B, member 14
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000404381
InnateDB Gene IDBG-31610 (DNAJB14)
Protein Structure
UniProt Annotation
Function Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER- associated degradation (ERAD) pathway. {ECO:0000269PubMed:23018488}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:23018488}; Single-pass membrane protein {ECO:0000269PubMed:23018488}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001623 DnaJ domain
IPR015399 Domain of unknown function DUF1977, DnaJ-like
PFAM PF00226
PF09320
PRINTS PR00625
PIRSF
SMART SM00271
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TBM8
PhosphoSite PhosphoSite-Q8TBM8
TrEMBL F2Z2L8
UniProt Splice Variant
Entrez Gene 79982
UniGene Hs.702072
RefSeq NP_001265239
HUGO HGNC:25881
OMIM
CCDS CCDS34035
HPRD 07013
IMGT
EMBL AC097460 AK023700 AK024343 AL833076 AP001962 AY186740 AY358272 BC022248 BX537609
GenPept AAH22248 AAO31693 AAQ88639 AAY41012 BAB14645 BAB14893 CAD89928 CAD97796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca