InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCEB3

Summary

InnateDB Protein

IDBP-374968.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCEB3

Protein Name

transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

Synonyms

EloA; SIII; SIII p110; TCEB3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000395574

InnateDB Gene

IDBG-93988 (TCEB3)

Protein Structure

UniProt Annotation

Function

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	21 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001810 F-box domain
IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR010684 RNA polymerase II transcription factor SIII, subunit A
IPR017923 Transcription factor IIS, N-terminal

PFAM

PF00646
PF12937
PF13013
PF06881
PF08711

PRINTS

PIRSF

SMART

SM00256
SM00509

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14241