InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DIO2

Summary

InnateDB Protein

IDBP-375045.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIO2

Protein Name

deiodinase, iodothyronine, type II

Synonyms

5DII; D2; DIOII; SelY; TXDI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000405854

InnateDB Gene

IDBG-14346 (DIO2)

Protein Structure

UniProt Annotation

Function

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004800	thyroxine 5'-deiodinase activity
GO:0008430	selenium binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001514	selenocysteine incorporation
GO:0006590	thyroid hormone generation
GO:0034641	cellular nitrogen compound metabolic process
GO:0042403	thyroid hormone metabolic process
GO:0042446	hormone biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process