InnateDB Protein
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IDBP-375054.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BANK1
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Protein Name
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B-cell scaffold protein with ankyrin repeats 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388817
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InnateDB Gene
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IDBG-31917 (BANK1)
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Protein Structure
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Function |
Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269PubMed:11782428}.
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Subcellular Localization |
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Disease Associations |
Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations. {ECO:0000269PubMed:11782428, ECO:0000269PubMed:18204447}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020683
Ankyrin repeat-containing domain
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PFAM |
PF11929
PF12796
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NDB2
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PhosphoSite |
PhosphoSite-Q8NDB2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55024
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UniGene |
Hs.582057
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RefSeq |
NP_001077376
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HUGO |
HGNC:18233
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OMIM |
610292
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CCDS |
CCDS47116
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HPRD |
09819
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IMGT |
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EMBL |
AB063170
AC093694
AC095062
AC109928
AK000713
AK091523
AK292133
AL834291
AP002075
BC032241
EU051376
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GenPept |
AAH32241
ABW74340
BAA91337
BAB79255
BAC03685
BAF84822
CAD38965
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