InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YTHDC2

Summary

InnateDB Protein

IDBP-37507.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YTHDC2

Protein Name

YTH domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000161863

InnateDB Gene

IDBG-37505 (YTHDC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	17 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008186	RNA-dependent ATPase activity
GO:0044822	poly(A) RNA binding
GO:0070063	RNA polymerase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0034612	response to tumor necrosis factor
GO:0044829	positive regulation by host of viral genome replication
GO:0070555	response to interleukin-1

Cellular Component

GO:0005783

endoplasmic reticulum

Protein Structure and Domains

PDB ID

InterPro

IPR001374 Single-stranded nucleic acid binding R3H
IPR001650 Helicase, C-terminal
IPR002110 Ankyrin repeat
IPR007275 YTH domain
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM