InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPAMD8

Summary

InnateDB Protein

IDBP-375094.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPAMD8

Protein Name

C3 and PZP-like, alpha-2-macroglobulin domain containing 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000402505

InnateDB Gene

IDBG-35910 (CPAMD8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted {ECO:0000305PubMed:15177561}. Cell membrane {ECO:0000269PubMed:15177561}; Peripheral membrane protein {ECO:0000269PubMed:15177561}; Extracellular side {ECO:0000269PubMed:15177561}.

Disease Associations

Tissue Specificity

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. {ECO:0000269PubMed:15177561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0010951

negative regulation of endopeptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001599 Alpha-2-macroglobulin
IPR002350 Kazal domain
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
IPR022041 Farnesoic acid O-methyl transferase

PFAM