InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FIGNL1

Summary

InnateDB Protein

IDBP-375222.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIGNL1

Protein Name

fidgetin-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410811

InnateDB Gene

IDBG-16569 (FIGNL1)

Protein Structure

UniProt Annotation

Function

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX- dependent manner. May regulate osteoblast proliferation and differentiation. {ECO:0000269PubMed:23754376}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23754376}. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0033687	osteoblast proliferation
GO:0043066	negative regulation of apoptotic process
GO:0046034	ATP metabolic process
GO:0051726	regulation of cell cycle
GO:0071479	cellular response to ionizing radiation
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000228	nuclear chromosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR015415 Vps4 oligomerisation, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF09336

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PIW4