InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2A1L

Summary

InnateDB Protein

IDBP-375368.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2A1L

Protein Name

general transcription factor IIA, 1-like

Synonyms

ALF;

Species

Homo sapiens

Ensembl Protein

ENSP00000387896

InnateDB Gene

IDBG-402606 (GTF2A1L)

Protein Structure

UniProt Annotation

Function

May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269PubMed:10364255}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16525715}. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.

Disease Associations

Tissue Specificity

Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis. {ECO:0000269PubMed:10364255, ECO:0000269PubMed:16525715}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0050890	cognition