InnateDB Protein
|
IDBP-375371.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MFNG
|
Protein Name
|
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000413855
|
InnateDB Gene
|
IDBG-6573 (MFNG)
|
Protein Structure
|
|
Function |
Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. {ECO:0000269PubMed:10935626}.
|
Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
0
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0016757
|
transferase activity, transferring glycosyl groups
|
GO:0033829
|
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003378
Fringe-like
IPR017374
Fringe
IPR029044
Nucleotide-diphospho-sugar transferases
|
PFAM |
PF02434
|
PRINTS |
|
PIRSF |
PIRSF038073
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O00587
|
PhosphoSite |
PhosphoSite-O00587
|
TrEMBL |
F6T992
|
UniProt Splice Variant |
|
Entrez Gene |
4242
|
UniGene |
Hs.599316
|
RefSeq |
NP_001159815
|
HUGO |
HGNC:7038
|
OMIM |
602577
|
CCDS |
CCDS54525
|
HPRD |
03988
|
IMGT |
|
EMBL |
AK297149
AK297833
AK316555
BC094814
CR456518
U94352
Z93096
|
GenPept |
AAC51358
AAH94814
BAG59648
BAG60167
BAG65633
CAB07511
CAG30404
CAP58791
CAP58792
|
|
|