Version 5.4
Homo sapiens Protein: DENND4A
Summary
InnateDB Protein IDBP-375580.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND4A
Protein Name DENN/MADD domain containing 4A
Synonyms IRLB; MYCPBP;
Species Homo sapiens
Ensembl Protein ENSP00000391167
InnateDB Gene IDBG-17699 (DENND4A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR002885 Pentatricopeptide repeat
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF01535
PF12854
PF13041
PF13812
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z401
PhosphoSite PhosphoSite-Q7Z401
TrEMBL
UniProt Splice Variant
Entrez Gene 10260
UniGene Hs.654567
RefSeq NP_001138295
HUGO HGNC:24321
OMIM 600382
CCDS CCDS53949
HPRD 02662
IMGT
EMBL AC011939 AF534403 AK091368 AL832602 AL833317 BC041706 X63417
GenPept AAH41706 AAQ10514 BAC03648 CAA45013 CAD89960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca