InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAPBP

Summary

InnateDB Protein

IDBP-375609.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAPBP

Protein Name

TAP binding protein (tapasin)

Synonyms

NGS17; TAPA; TPN; TPSN;

Species

Homo sapiens

Ensembl Protein

ENSP00000395701

InnateDB Gene

IDBG-304230 (TAPBP)

Protein Structure

UniProt Annotation

Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269PubMed:10636848}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Neutrophils, mostly in fully differentiated cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015433	peptide antigen-transporting ATPase activity
GO:0042288	MHC class I protein binding
GO:0042605	peptide antigen binding
GO:0046978	TAP1 binding
GO:0046979	TAP2 binding
GO:0051082	unfolded protein binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006461	protein complex assembly
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0006955	immune response
GO:0015833	peptide transport
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042886	amide transport
GO:0050823	peptide antigen stabilization

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0042824	MHC class I peptide loading complex
GO:0042825	TAP complex
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane