InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAPBP

Summary

InnateDB Protein

IDBP-375615.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAPBP

Protein Name

TAP binding protein (tapasin)

Synonyms

NGS17; TAPA; TPN; TPSN;

Species

Homo sapiens

Ensembl Protein

ENSP00000404833

InnateDB Gene

IDBG-304230 (TAPBP)

Protein Structure

UniProt Annotation

Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269PubMed:10636848}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Neutrophils, mostly in fully differentiated cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002397	MHC class I protein complex assembly
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006952	defense response
GO:0050823	peptide antigen stabilization