InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBP1

Summary

InnateDB Protein

IDBP-375664.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBP1

Protein Name

fructose-1,6-bisphosphatase 1

Synonyms

FBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000408025

InnateDB Gene

IDBG-76936 (FBP1)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269PubMed:16497803, ECO:0000269PubMed:18375435, ECO:0000269PubMed:22517657}.

Subcellular Localization

Disease Associations

Fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:229700]: Inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children. {ECO:0000269PubMed:12126934, ECO:0000269PubMed:9382095}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in pancreatic islets. {ECO:0000269PubMed:18375435}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016208	AMP binding
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006111	regulation of gluconeogenesis
GO:0016311	dephosphorylation
GO:0030308	negative regulation of cell growth
GO:0035690	cellular response to drug
GO:0044281	small molecule metabolic process
GO:0045820	negative regulation of glycolytic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046854	phosphatidylinositol phosphorylation
GO:0051289	protein homotetramerization
GO:0071286	cellular response to magnesium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000146 Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase
IPR000760 Inositol monophosphatase
IPR023079 Sedoheptulose-1,7-bisphosphatase
IPR028343 Fructose-1,6-bisphosphatase

PFAM

PF00316
PF00459

PRINTS

PR00377
PR01958
PR00115

PIRSF

PIRSF000904
PIRSF500210

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt