Homo sapiens Protein: PSKH1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-37574.4 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PSKH1 | ||||||||||||||||||
Protein Name | protein serine kinase H1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000291041 | ||||||||||||||||||
InnateDB Gene | IDBG-37572 (PSKH1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. {ECO:0000269PubMed:12466556}. | ||||||||||||||||||
Subcellular Localization | Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in all tissues and cell lines tested with the highest level of abundance in testis. {ECO:0000269PubMed:11087665}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P11801 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P11801 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 5681 | ||||||||||||||||||
UniGene | Hs.513683 | ||||||||||||||||||
RefSeq | NP_006733 | ||||||||||||||||||
HUGO | HGNC:9529 | ||||||||||||||||||
OMIM | 177015 | ||||||||||||||||||
CCDS | CCDS10851 | ||||||||||||||||||
HPRD | 01511 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AJ272212 BC062616 M14504 | ||||||||||||||||||
GenPept | AAA36519 AAH62616 CAB91984 | ||||||||||||||||||