InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAI1

Summary

InnateDB Protein

IDBP-37584.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAI1

Protein Name

brain-specific angiogenesis inhibitor 1

Synonyms

GDAIF;

Species

Homo sapiens

Ensembl Protein

ENSP00000313046

InnateDB Gene

IDBG-37582 (BAI1)

Protein Structure

UniProt Annotation

Function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. {ECO:0000269PubMed:11875720}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12074842}; Multi-pass membrane protein {ECO:0000269PubMed:12074842}. Note=Likely to be concentrated at cell-cell adhesion sites.

Disease Associations

Tissue Specificity

Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes. {ECO:0000269PubMed:11875720, ECO:0000269PubMed:12074842, ECO:0000269PubMed:12507886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007409	axonogenesis
GO:0007422	peripheral nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0016525	negative regulation of angiogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR000884 Thrombospondin, type 1 repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497

PFAM

PF01825
PF00002
PF00090
PF02793
PF12003

PRINTS

PR00249
PR01694

PIRSF

SMART

SM00303
SM00209
SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt