InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASRGL1

Summary

InnateDB Protein

IDBP-375996.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASRGL1

Protein Name

asparaginase like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000400057

InnateDB Gene

IDBG-50970 (ASRGL1)

Protein Structure

UniProt Annotation

Function

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. {ECO:0000269PubMed:19839645}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11984834}. Note=Midpiece of sperm tail.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269PubMed:11984834, ECO:0000269PubMed:14654938}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004067	asparaginase activity
GO:0008798	beta-aspartyl-peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0033345	asparagine catabolic process via L-aspartate

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000246 Peptidase T2, asparaginase 2
IPR029055 Nucleophile aminohydrolases, N-terminal

PFAM

PF01112

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7L266

PhosphoSite

PhosphoSite-Q7L266

TrEMBL

Q9BRH2

UniProt Splice Variant

Entrez Gene

80150

UniGene

Hs.710746

RefSeq

NP_001077395

HUGO

HGNC:16448

OMIM

609212

CCDS

CCDS8019

HPRD

07006

IMGT

EMBL

AF411076 AK025969 AK091894 AK313069 BC006267 BC021295 BC064963 BC093070 CH471076

GenPept

AAH06267 AAH21295 AAH64963 AAH93070 AAM28434 BAB15302 BAG35897 BAG52437 EAW74012 EAW74013 EAW74017