InnateDB Protein
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IDBP-376241.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CATSPER4
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Protein Name
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cation channel, sperm associated 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000390423
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InnateDB Gene
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IDBG-94509 (CATSPER4)
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Protein Structure
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Function |
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269PubMed:21412338, ECO:0000269PubMed:21412339}.
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Subcellular Localization |
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
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Disease Associations |
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Tissue Specificity |
Testis-specific. {ECO:0000269PubMed:12932298, ECO:0000269PubMed:17347248}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005821
Ion transport domain
IPR013122
Polycystin cation channel, PKD1/PKD2
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PFAM |
PF00520
PF08016
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7RTX7
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PhosphoSite |
PhosphoSite-Q7RTX7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
378807
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UniGene |
Hs.733788
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RefSeq |
NP_937770
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HUGO |
HGNC:23220
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OMIM |
609121
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CCDS |
CCDS30645
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HPRD |
18607
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IMGT |
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EMBL |
AL355877
BC128138
BC128139
BN000273
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GenPept |
AAI28139
AAI28140
CAE30475
CAH71538
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