InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARC

Summary

InnateDB Protein

IDBP-37636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARC

Protein Name

activity-regulated cytoskeleton-associated protein

Synonyms

Arg3.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349022

InnateDB Gene

IDBG-37634 (ARC)

Protein Structure

UniProt Annotation

Function

Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269PubMed:21834987}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250UniProtKB:Q63053, ECO:0000250UniProtKB:Q9WV31}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250UniProtKB:Q63053, ECO:0000250UniProtKB:Q9WV31}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269PubMed:21834987}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007492	endoderm development
GO:0007612	learning
GO:0009952	anterior/posterior pattern specification
GO:0016477	cell migration
GO:0022604	regulation of cell morphogenesis
GO:0048168	regulation of neuronal synaptic plasticity

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane