InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF4

Summary

InnateDB Protein

IDBP-37649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF4

Protein Name

TNF receptor-associated factor 4

Synonyms

CART1; MLN62; RNF83;

Species

Homo sapiens

Ensembl Protein

ENSP00000262396

InnateDB Gene

IDBG-37645 (TRAF4)

Protein Structure

UniProt Annotation

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. {ECO:0000250, ECO:0000269PubMed:12023963, ECO:0000269PubMed:12801526, ECO:0000269PubMed:16052631, ECO:0000269PubMed:16157600, ECO:0000269PubMed:18953416, ECO:0000269PubMed:19937093}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. {ECO:0000269PubMed:7592751, ECO:0000269PubMed:9626059}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	90 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding
GO:0046872	metal ion binding
GO:0050699	WW domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0016567	protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0090073	positive regulation of protein homodimerization activity