InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A6

Summary

InnateDB Protein

IDBP-376638.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A6

Protein Name

solute carrier family 22 (organic anion transporter), member 6

Synonyms

HOAT1; OAT1; PAHT; ROAT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000396401

InnateDB Gene

IDBG-52241 (SLC22A6)

Protein Structure

UniProt Annotation

Function

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. {ECO:0000250, ECO:0000269PubMed:12538807, ECO:0000269PubMed:15644426, ECO:0000269PubMed:17038320, ECO:0000269PubMed:17502342, ECO:0000269PubMed:9762842, ECO:0000269PubMed:9887087}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269PubMed:10049739, ECO:0000269PubMed:10462545, ECO:0000269PubMed:10964714, ECO:0000269PubMed:9887087, ECO:0000269PubMed:9950961}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005452	inorganic anion exchanger activity
GO:0005515	protein binding
GO:0008514	organic anion transmembrane transporter activity
GO:0015075	ion transmembrane transporter activity
GO:0015347	sodium-independent organic anion transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0015711	organic anion transport
GO:0015742	alpha-ketoglutarate transport
GO:0034220	ion transmembrane transport
GO:0043252	sodium-independent organic anion transport
GO:0055085	transmembrane transport
GO:0097254	renal tubular secretion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4U2R8

PhosphoSite