InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO9A

Summary

InnateDB Protein

IDBP-376721.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO9A

Protein Name

myosin IXA

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000398250

InnateDB Gene

IDBG-19982 (MYO9A)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Found to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis. {ECO:0000269PubMed:10409426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0016459	myosin complex
GO:0016461	unconventional myosin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001609 Myosin head, motor domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM

PF00612
PF00788
PF00620
PF00063
PF00130

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00314
SM00324
SM00242
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt