InnateDB Protein
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IDBP-376778.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SERPINA9
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Protein Name
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serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414092
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InnateDB Gene
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IDBG-18262 (SERPINA9)
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Protein Structure
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Function |
Protease inhibitor that inhibits trypsin and trypsin- like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). {ECO:0000269PubMed:17447896}.
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Subcellular Localization |
Isoform 1: Secreted.Isoform 2: Cytoplasm {ECO:0000305}.Isoform 3: Cytoplasm {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.Isoform 5: Cytoplasm {ECO:0000305}.Isoform 6: Cytoplasm {ECO:0000305}.Isoform 7: Membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies. {ECO:0000269PubMed:12819018, ECO:0000269PubMed:17447896, ECO:0000269PubMed:17898315, ECO:0000269PubMed:18550480}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004867
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serine-type endopeptidase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR023796
Serpin domain
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PFAM |
PF00079
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PRINTS |
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PIRSF |
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SMART |
SM00093
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TIGRFAMs |
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Modification |
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SwissProt |
Q86WD7
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PhosphoSite |
PhosphoSite-Q86WD7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
327657
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UniGene |
Hs.317970
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RefSeq |
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HUGO |
HGNC:15995
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OMIM |
615677
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CCDS |
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HPRD |
11546
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IMGT |
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EMBL |
AK301082
AL132708
AY185496
AY185497
AY220118
AY220119
AY220120
AY220121
AY358700
BC111498
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GenPept |
AAI11499
AAO32345
AAO32346
AAO65242
AAO65243
AAO65244
AAO65245
AAQ89063
BAG62686
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