InnateDB Protein
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IDBP-376908.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRAPPC9
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Protein Name
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trafficking protein particle complex 9
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000405060
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InnateDB Gene
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IDBG-36970 (TRAPPC9)
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Protein Structure
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Function |
Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269PubMed:15951441}.
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Subcellular Localization |
Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Processes and cell bodies of neurons. {ECO:0000250}.
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Disease Associations |
Mental retardation, autosomal recessive 13 (MRT13) [MIM:613192]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals. {ECO:0000269PubMed:20004763, ECO:0000269PubMed:20004765}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta. {ECO:0000269PubMed:15951441}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013935
TRAPP II complex, Trs120
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PFAM |
PF08626
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96Q05
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PhosphoSite |
PhosphoSite-Q96Q05
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83696
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UniGene |
Hs.690965
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RefSeq |
NP_001153844
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HUGO |
HGNC:30832
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OMIM |
611966
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CCDS |
CCDS55278
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HPRD |
18136
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IMGT |
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EMBL |
AB067469
AK027689
AK128755
AL833973
AY190606
AY630619
BC003650
BC006206
BC065288
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GenPept |
AAH03650
AAH06206
AAH65288
AAO38740
AAV31908
BAB55299
BAB67775
BAC87600
CAH56384
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