InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCD

Summary

InnateDB Protein

IDBP-377004.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCD

Protein Name

dermcidin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406773

InnateDB Gene

IDBG-38275 (DCD)

Protein Structure

UniProt Annotation

Function

DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008233	peptidase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050832	defense response to fungus