InnateDB Protein
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IDBP-377028.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TESPA1
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Protein Name
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KIAA0748
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Synonyms
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KIAA0748;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000400892
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InnateDB Gene
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IDBG-38320 (TESPA1)
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Protein Structure
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Function |
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269PubMed:22561606}.
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Subcellular Localization |
Cytoplasm. Endoplasmic reticulum membrane. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM).
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0010387
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COP9 signalosome assembly
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GO:0033089
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positive regulation of T cell differentiation in thymus
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GO:0050862
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positive regulation of T cell receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A2RU30
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PhosphoSite |
PhosphoSite-A2RU30
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TrEMBL |
E9PN46
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UniProt Splice Variant |
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Entrez Gene |
9840
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UniGene |
Hs.33187
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RefSeq |
NP_001129502
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HUGO |
HGNC:29109
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OMIM |
615664
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CCDS |
CCDS44913
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HPRD |
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IMGT |
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EMBL |
AB018291
AC079842
AF161375
AK295026
AK298405
AK303223
AK315972
BC044578
BC132732
BC132734
CH471054
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GenPept |
AAF28935
AAH44578
AAI32733
AAI32735
BAA34468
BAG58082
BAG60635
BAG64310
BAH14343
EAW96796
EAW96798
EAW96799
EAW96800
EAW96801
EAW96802
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