InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPX1

Summary

InnateDB Protein

IDBP-377185.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPX1

Protein Name

glutathione peroxidase 1

Synonyms

GPXD; GSHPX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000407375

InnateDB Gene

IDBG-305033 (GPX1)

Protein Structure

UniProt Annotation

Function

Protects the hemoglobin in erythrocytes from oxidative breakdown.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0008430	selenium binding
GO:0017124	SH3 domain binding
GO:0043295	glutathione binding
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001659	temperature homeostasis
GO:0001885	endothelial cell development
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006749	glutathione metabolic process
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0006982	response to lipid hydroperoxide
GO:0007568	aging
GO:0007605	sensory perception of sound
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410	response to xenobiotic stimulus
GO:0009609	response to symbiotic bacterium
GO:0009611	response to wounding
GO:0009636	response to toxic substance
GO:0009650	UV protection
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0010269	response to selenium ion
GO:0010332	response to gamma radiation
GO:0014070	response to organic cyclic compound
GO:0014902	myotube differentiation
GO:0018158	protein oxidation
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0032355	response to estradiol
GO:0033194	response to hydroperoxide
GO:0033599	regulation of mammary gland epithelial cell proliferation
GO:0035094	response to nicotine
GO:0040029	regulation of gene expression, epigenetic
GO:0042311	vasodilation
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0043523	regulation of neuron apoptotic process
GO:0043534	blood vessel endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045444	fat cell differentiation
GO:0045454	cell redox homeostasis
GO:0048741	skeletal muscle fiber development
GO:0051450	myoblast proliferation
GO:0051593	response to folic acid
GO:0051702	interaction with symbiont
GO:0051897	positive regulation of protein kinase B signaling
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0060055	angiogenesis involved in wound healing
GO:0061136	regulation of proteasomal protein catabolic process
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway