InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDGA1

Summary

InnateDB Protein

IDBP-377405.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDGA1

Protein Name

MAM domain containing glycosylphosphatidylinositol anchor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000402584

InnateDB Gene

IDBG-85735 (MDGA1)

Protein Structure

UniProt Annotation

Function

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO:0000250, ECO:0000269PubMed:23248271}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15922729}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:15922729}. Note=Associated with lipid rafts.

Disease Associations

Tissue Specificity

Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0007420	brain development
GO:0021527	spinal cord association neuron differentiation
GO:0021799	cerebral cortex radially oriented cell migration

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0046658	anchored component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000998 MAM domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00629
PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PR00020

PIRSF

SMART

SM00137
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt