Version 5.4
Homo sapiens Protein: ISLR2
Summary
InnateDB Protein IDBP-377418.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISLR2
Protein Name immunoglobulin superfamily containing leucine-rich repeat 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408872
InnateDB Gene IDBG-21815 (ISLR2)
Protein Structure
UniProt Annotation
Function Required for axon extension during neural development. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045773 positive regulation of axon extension
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXK2
PhosphoSite PhosphoSite-Q6UXK2
TrEMBL Q24JQ5
UniProt Splice Variant
Entrez Gene 57611
UniGene Hs.254775
RefSeq
HUGO HGNC:29286
OMIM 614179
CCDS
HPRD 13865
IMGT
EMBL AB040898 AC010931 AK290467 AY358316 BC114551
GenPept AAI14552 AAQ88682 BAA95989 BAF83156

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca