Version 5.4
Homo sapiens Protein: CTNNA3
Summary
InnateDB Protein IDBP-377553.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNA3
Protein Name catenin (cadherin-associated protein), alpha 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000389714
InnateDB Gene IDBG-75710 (CTNNA3)
Protein Structure
UniProt Annotation
Function May be involved in formation of stretch-resistant cell- cell adhesion complexes. {ECO:0000303PubMed:11590244}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000305}. Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. {ECO:0000269PubMed:11590244}.
Disease Associations Arrhythmogenic right ventricular dysplasia, familial, 13 (ARVD13) [MIM:615616]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. {ECO:0000269PubMed:23136403}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. {ECO:0000269PubMed:11590244}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005916 fascia adherens
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR001033 Alpha-catenin
IPR006077 Vinculin/alpha-catenin
IPR017997 Vinculin
PFAM PF01044
PRINTS PR00805
PR00806
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UI47
PhosphoSite PhosphoSite-Q9UI47
TrEMBL Q5SW23
UniProt Splice Variant
Entrez Gene 29119
UniGene Hs.660362
RefSeq NP_037398
HUGO HGNC:2511
OMIM 607667
CCDS CCDS7269
HPRD 09639
IMGT
EMBL AC016819 AC018979 AC020642 AC022017 AC022029 AC022401 AC022534 AC026394 AC069536 AF091606 AF282679 AF282680 AF282681 AF282682 AF282683 AF282684 AF282685 AF282686 AF282687 AF282688 AF282689 AF282690 AF282691 AF282692 AF391792 AF391793 AF391794 AL139240 AL592075 AL607022 AL607023 AL713957 AL731538 AL731549 BC065819
GenPept AAF21801 AAH65819 AAQ14328 CAH70164 CAH73988 CAI13390 CAI16316

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca