InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPI

Summary

InnateDB Protein

IDBP-377643.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPI

Protein Name

centromere protein I

Synonyms

CENP-I; FSHPRH1; LRPR1; Mis6;

Species

Homo sapiens

Ensembl Protein

ENSP00000399274

InnateDB Gene

IDBG-79496 (CENPI)

Protein Structure

UniProt Annotation

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269PubMed:12640463, ECO:0000269PubMed:16622420}.

Subcellular Localization

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006334	nucleosome assembly
GO:0007548	sex differentiation
GO:0034080	centromere-specific nucleosome assembly
GO:0034508	centromere complex assembly