InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A17

Summary

InnateDB Protein

IDBP-377745.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A17

Protein Name

solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17

Synonyms

PMP34;

Species

Homo sapiens

Ensembl Protein

ENSP00000390722

InnateDB Gene

IDBG-8857 (SLC25A17)

Protein Structure

UniProt Annotation

Function

Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. {ECO:0000269PubMed:12445829, ECO:0000269PubMed:22185573}.

Subcellular Localization

Cytoplasm. Peroxisome membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed in liver. {ECO:0000269PubMed:22185573}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005347	ATP transmembrane transporter activity
GO:0005515	protein binding
GO:0015217	ADP transmembrane transporter activity
GO:0015228	coenzyme A transmembrane transporter activity
GO:0015230	FAD transmembrane transporter activity
GO:0044610	FMN transmembrane transporter activity
GO:0051087	chaperone binding
GO:0051724	NAD transporter activity
GO:0080122	AMP transmembrane transporter activity

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006635	fatty acid beta-oxidation
GO:0015866	ADP transport
GO:0015867	ATP transport
GO:0015908	fatty acid transport
GO:0035349	coenzyme A transmembrane transport
GO:0035350	FAD transmembrane transport
GO:0043132	NAD transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0080121	AMP transport
GO:1901679	nucleotide transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle