Homo sapiens Protein: FEM1C
Summary
InnateDB Protein IDBP-37783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEM1C
Protein Name fem-1 homolog c (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000274457
InnateDB Gene IDBG-37781 (FEM1C)
Protein Structure
UniProt Annotation
Function Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage. {ECO:0000269PubMed:11733146, ECO:0000269PubMed:14527725}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JP0
PhosphoSite PhosphoSite-Q96JP0
TrEMBL
UniProt Splice Variant
Entrez Gene 56929
UniGene Hs.597539
RefSeq NP_064562
HUGO HGNC:16933
OMIM 608767
CCDS CCDS4118
HPRD 16384
IMGT
EMBL AB058688 AF391093 AK025265 AK315803 AL365409 AL365415 AL831817 AY249188 BC028369 CH471086
GenPept AAH28369 AAL37627 AAO64429 BAB15096 BAB47414 BAG38144 CAB96953 CAB96957 CAD38531 EAW48963