Version 5.4
Homo sapiens Protein: CLDN4
Summary
InnateDB Protein IDBP-377877.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN4
Protein Name claudin 4
Synonyms CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8;
Species Homo sapiens
Ensembl Protein ENSP00000388639
InnateDB Gene IDBG-20463 (CLDN4)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.
Subcellular Localization Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations Note=CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0007165 signal transduction
GO:0016338 calcium-independent cell-cell adhesion
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003550 Claudin-4
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01379
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14493
PhosphoSite PhosphoSite-O14493
TrEMBL Q75L80
UniProt Splice Variant
Entrez Gene 1364
UniGene Hs.729359
RefSeq
HUGO HGNC:2046
OMIM 602909
CCDS CCDS5560
HPRD 04218
IMGT
EMBL AB000712 AC093168 AK124076 AK126315 BC000671 BT006989 CH471200
GenPept AAH00671 AAP35635 AAS07556 BAA22984 BAG54000 BAG54307 EAW69639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca