InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPRED2

Summary

InnateDB Protein

IDBP-377950.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPRED2

Protein Name

sprouty-related, EVH1 domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000393697

InnateDB Gene

IDBG-54314 (SPRED2)

Protein Structure

UniProt Annotation

Function

Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.

Disease Associations

Tissue Specificity

Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269PubMed:15580519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005173	stem cell factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311	regulation of protein deacetylation