InnateDB Protein
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IDBP-377996.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTBP3
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Protein Name
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ROD1 regulator of differentiation 1 (S. pombe)
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Synonyms
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ROD1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414921
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InnateDB Gene
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IDBG-81247 (PTBP3)
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Protein Structure
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Function |
RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269PubMed:10207106, ECO:0000269PubMed:18335065, ECO:0000269PubMed:19441079, ECO:0000269PubMed:20937273}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in several hematopoietic cell lines examined. {ECO:0000269PubMed:10207106}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR006536
HnRNP-L/PTB/hephaestus splicing factor
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
O95758
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PhosphoSite |
PhosphoSite-O95758
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TrEMBL |
X6R242
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UniProt Splice Variant |
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Entrez Gene |
9991
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UniGene |
Hs.621703
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RefSeq |
NP_001231827
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HUGO |
HGNC:10253
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OMIM |
607527
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CCDS |
CCDS59141
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HPRD |
09603
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IMGT |
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EMBL |
AB023967
AK001685
AK302558
AL158824
AL359073
BC039896
BC044585
BI463123
CH471105
CR749471
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GenPept |
AAH39896
AAH44585
BAA75466
BAG50959
BAG63824
CAH18301
CAI12349
CAI12350
CAI12353
CAI12354
CAI14112
CAI14113
EAW59100
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