InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB3A

Summary

InnateDB Protein

IDBP-37809.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB3A

Protein Name

RAB3A, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222256

InnateDB Gene

IDBG-37807 (RAB3A)

Protein Structure

UniProt Annotation

Function

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0051020	GTPase binding
GO:0051117	ATPase binding

Biological Process

GO:0003016	respiratory system process
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007005	mitochondrion organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007274	neuromuscular synaptic transmission
GO:0007409	axonogenesis
GO:0009791	post-embryonic development
GO:0014047	glutamate secretion
GO:0015031	protein transport
GO:0016079	synaptic vesicle exocytosis
GO:0016188	synaptic vesicle maturation
GO:0017157	regulation of exocytosis
GO:0030324	lung development
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane
GO:0032781	positive regulation of ATPase activity
GO:0048790	maintenance of presynaptic active zone structure
GO:0050975	sensory perception of touch
GO:0051602	response to electrical stimulus

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0030424	axon
GO:0043195	terminal bouton
GO:0043229	intracellular organelle
GO:0043234	protein complex
GO:0060201	clathrin-sculpted acetylcholine transport vesicle membrane
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt