|
InnateDB Protein
|
IDBP-378101.5
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
FKBP15
|
|
Protein Name
|
FK506 binding protein 15, 133kDa
|
|
Synonyms
|
FKBP133; KIAA0674; PPP1R76;
|
|
Species
|
Homo sapiens
|
|
Ensembl Protein
|
ENSP00000415733
|
|
InnateDB Gene
|
IDBG-81519 (FKBP15)
|
|
Protein Structure
|
|
| Function |
May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement. {ECO:0000250, ECO:0000269PubMed:19121306}.
|
| Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}. Early endosome {ECO:0000269PubMed:19121306}. Note=Present in axons and neuronal growth cones. {ECO:0000250}.
|
| Disease Associations |
|
| Tissue Specificity |
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
12
[view]
|
| Protein-Protein |
12
[view]
|
| Protein-DNA |
0
|
| Protein-RNA |
0
|
| DNA-DNA |
0
|
| RNA-RNA |
0
|
| DNA-RNA |
0
|
|
| Predicted by orthology |
| Total |
1 [view]
|
|
|
Molecular Function |
| Accession |
GO Term |
|
GO:0003755
|
peptidyl-prolyl cis-trans isomerase activity
|
|
| Biological Process |
|
| Cellular Component |
|
| PDB ID |
|
| InterPro |
IPR001179
Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
|
| PFAM |
PF00254
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
|
| PhosphoSite |
PhosphoSite-Q5T1M5
|
| TrEMBL |
X6RKW4
|
| UniProt Splice Variant |
|
| Entrez Gene |
23307
|
| UniGene |
Hs.703312
|
| RefSeq |
|
| HUGO |
HGNC:23397
|
| OMIM |
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
AL449105
AL449305
|
| GenPept |
|
|
|
|
Version 5.4