InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETFA

Summary

InnateDB Protein

IDBP-378211.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETFA

Protein Name

electron-transfer-flavoprotein, alpha polypeptide

Synonyms

EMA; GA2; MADD;

Species

Homo sapiens

Ensembl Protein

ENSP00000399273

InnateDB Gene

IDBG-23927 (ETFA)

Protein Structure

UniProt Annotation

Function

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Glutaric aciduria 2A (GA2A) [MIM:231680]: An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. {ECO:0000269PubMed:1430199, ECO:0000269PubMed:1882842}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001308 Electron transfer flavoprotein, alpha subunit
IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF01012
PF00766

PRINTS

PIRSF

PIRSF000089

SMART

SM00893

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt