InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF26A

Summary

InnateDB Protein

IDBP-378286.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF26A

Protein Name

kinesin family member 26A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000388241

InnateDB Gene

IDBG-22450 (KIF26A)

Protein Structure

UniProt Annotation

Function

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0001560	regulation of cell growth by extracellular stimulus
GO:0007018	microtubule-based movement
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009968	negative regulation of signal transduction
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0048484	enteric nervous system development