InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO1A

Summary

InnateDB Protein

IDBP-378322.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1A

Protein Name

myosin IA

Synonyms

BBMI; DFNA48; MIHC; MYHL;

Species

Homo sapiens

Ensembl Protein

ENSP00000393392

InnateDB Gene

IDBG-41918 (MYO1A)

Protein Structure

UniProt Annotation

Function

Involved in directing the movement of organelles along actin filaments. {ECO:0000305}.

Subcellular Localization

Disease Associations

Deafness, autosomal dominant, 48 (DFNA48) [MIM:607841]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:12736868}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0030030	cell projection organization
GO:0030033	microvillus assembly
GO:0051648	vesicle localization

Cellular Component

GO:0005737	cytoplasm
GO:0005902	microvillus
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0016459	myosin complex
GO:0030864	cortical actin cytoskeleton
GO:0031941	filamentous actin

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF06017

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt