InnateDB Protein
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IDBP-378363.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2V1
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Protein Name
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ubiquitin-conjugating enzyme E2 variant 1
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Synonyms
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CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000407770
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InnateDB Gene
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IDBG-408829 (UBE2V1)
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Protein Structure
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Function |
Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {ECO:0000269PubMed:11057907, ECO:0000269PubMed:20061386, ECO:0000269PubMed:21512573, ECO:0000269PubMed:9305758, ECO:0000269PubMed:9418904, ECO:0000269PubMed:9580084, ECO:0000269PubMed:9705497}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11076860, ECO:0000269PubMed:9305758}. Note=Excluded from the nucleolus.
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Disease Associations |
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Tissue Specificity |
Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. {ECO:0000269PubMed:9418904, ECO:0000269PubMed:9705497}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
128
[view]
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Protein-Protein |
128
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000209
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protein polyubiquitination
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GO:0002224
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toll-like receptor signaling pathway
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GO:0002755
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MyD88-dependent toll-like receptor signaling pathway
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GO:0006282
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regulation of DNA repair
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0030154
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cell differentiation
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GO:0034134
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toll-like receptor 2 signaling pathway
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GO:0034142
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toll-like receptor 4 signaling pathway
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GO:0034146
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toll-like receptor 5 signaling pathway
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GO:0034162
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toll-like receptor 9 signaling pathway
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GO:0034166
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toll-like receptor 10 signaling pathway
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GO:0035872
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nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0038123
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toll-like receptor TLR1:TLR2 signaling pathway
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GO:0038124
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toll-like receptor TLR6:TLR2 signaling pathway
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045087
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innate immune response
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0050852
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T cell receptor signaling pathway
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0070423
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nucleotide-binding oligomerization domain containing signaling pathway
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GO:0070534
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protein K63-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13404
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PhosphoSite |
PhosphoSite-Q13404
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7335
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UniGene |
Hs.741376
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RefSeq |
NP_071887
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HUGO |
HGNC:12494
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OMIM |
602995
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CCDS |
CCDS13427
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HPRD |
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IMGT |
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EMBL |
AL034423
AY008273
BC000468
BC008944
BT007382
CH471077
DA580976
U39360
U39361
U49278
U97279
U97280
U97281
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GenPept |
AAB72015
AAB72016
AAC02755
AAC02756
AAC02757
AAC02780
AAG24229
AAH00468
AAH08944
AAP36046
CAB76864
CAB76865
CAC16954
CAC16955
CAI19382
CAI19383
EAW75634
EAW75635
EAW75636
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