InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MORF4L2

Summary

InnateDB Protein

IDBP-378370.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MORF4L2

Protein Name

mortality factor 4 like 2

Synonyms

MORFL2; MRGX;

Species

Homo sapiens

Ensembl Protein

ENSP00000416120

InnateDB Gene

IDBG-80774 (MORF4L2)

Protein Structure

UniProt Annotation

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0040008	regulation of growth