Version 5.4
Homo sapiens Protein: FAM60A
Summary
InnateDB Protein IDBP-378472.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM60A
Protein Name family with sequence similarity 60, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393279
InnateDB Gene IDBG-25948 (FAM60A)
Protein Structure
UniProt Annotation
Function Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. {ECO:0000269PubMed:22865885, ECO:0000269PubMed:22984288}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030336 negative regulation of cell migration
Cellular Component
GO:0016580 Sin3 complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP50
PhosphoSite PhosphoSite-Q9NP50
TrEMBL F5H6U2
UniProt Splice Variant
Entrez Gene 58516
UniGene Hs.729794
RefSeq XP_005253513
HUGO HGNC:30702
OMIM 615027
CCDS CCDS8723
HPRD 16588
IMGT
EMBL AC024940 AF087885 AF212220 AK026932 AK294457 AL157432 AY598323 BC000024 BC004462 BC071966 CH471116
GenPept AAF87322 AAH00024 AAH04462 AAH71966 AAP97184 AAT06734 BAB15592 BAH11773 CAB75656 EAW88561 EAW88562 EAW88564 EAW88566 EAW88567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca