Version 5.4
| Homo sapiens Protein: GPR84 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-37855.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | GPR84 | ||||||
| Protein Name | G protein-coupled receptor 84 | ||||||
| Synonyms | |||||||
| Species | Homo sapiens | ||||||
| Ensembl Protein | ENSP00000267015 | ||||||
| InnateDB Gene | IDBG-37853 (GPR84) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. {ECO:0000269PubMed:16966319}. | ||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes. {ECO:0000269PubMed:11273702, ECO:0000269PubMed:11404393, ECO:0000269PubMed:16966319}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | |||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR017452 GPCR, rhodopsin-like, 7TM IPR019430 7TM GPCR, serpentine receptor class x (Srx) |
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| PFAM |
PF00001
PF10328 |
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| PRINTS |
PR00237
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| PIRSF | |||||||
| SMART | |||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q9NQS5 | ||||||
| PhosphoSite | PhosphoSite-Q9NQS5 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 53831 | ||||||
| UniGene | Hs.306199 | ||||||
| RefSeq | NP_065103 | ||||||
| HUGO | HGNC:4535 | ||||||
| OMIM | 606383 | ||||||
| CCDS | CCDS8878 | ||||||
| HPRD | 16213 | ||||||
| IMGT | |||||||
| EMBL | AB083586 AF237762 AF282693 BC020614 CH471054 FJ348261 | ||||||
| GenPept | AAF91467 AAH20614 AAK01857 ACI96305 BAB89299 EAW96776 | ||||||